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Apostle Triton 生物信息学技术

Apostle Triton 是一个生物信息学技术框架，基于应用超过30,000名癌症患者的内部注释数据库以产生高精度的数据分析。


Background

  • Cancer is a genetically heterogeneous disease.
  • Somatic mutations exist in both cancer and normal cells.
  • We still know very little about the genetics of cancer. There is a lacking of a comprehensive and coherent way to mine the big data repository of cancer genetics and apply the applicable findings.
  • The clinical application of liquid biopsy is further complicated by the characteristics of cell free tumor nucleic acids: low concentration, complex fragmentation, etc.

Here, we introduce Apostle Triton, a bioinformatics framework designed for liquid biopsy, which utilizes the big data from cancer genomics, evaluates disease effects of somatic mutations/variants and expression signatures, and apply the findings in the settings of liquid biopsy.

Apostle Triton Website
Nature 子刊 Nature Communications 近期发表又一项高影响力国际临床研究，其中应用 Apostle 艾铂图 MiniMax 游离核酸技术。此研究包括2125名癌症患者，9种不同的癌症类型。此研究表明，应用cfDNA游离核酸技术，可以有效、高敏感度地检测早期癌症。Apostle 艾铂图 MiniMax 游离核酸技术不断在国际上得到广泛的应用，迄今，已发表、被引用 Nature 子刊 3篇 ( Nature Medicine X 2, Nature Communications X 1)， Science 子刊 1 篇， PNAS 1 篇，各种临床研究50余篇等。 祝贺此临床研究团队！期待Apostle 艾铂图技术更好地为人类做贡献。