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Apostle MiniMax 高效游离 DNA 分离试剂盒 (S 版)

特别设计用于DNA 小片段分离 (<100 bp) 


Overview, Apostle MiniMax (Type S)

Powered by Apostle MiniMax technology, Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S) is an excellent tool for the isolation of ultra-low concentration cell free DNA (cfDNA). Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S) is featured for its efficient recovery of small DNA fragments ( <100 bp) from biological samples, where major alternative products fail. This feature is quite useful when small DNA molecules have significant presence in the biological sample and need to be isolated.


ProductsCat #Protocol
Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S) (25-50 preps)
A17830-50
Download Protocol
Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S) (5-10 preps)
A17830-10
Download Protocol


Performance Data

Compared to major alternative suppliers with magnetic bead technology, Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S) offers superior DNA isolation efficiency for cfDNA reference spiked in biological medium, especially for cfDNA with size <80 bp (Exhibit 1-3).

Exhibit 1. Superior small DNA isolation efficiency.

A) cfDNA reference standard (Horizon Discovery Ltd, Cat# HD780) was spiked in TE buffer, followed by isolation with Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S). The isolated DNA was characterized by Bioanalyzer 2100 (red curve), and compared with original cfDNA reference standard (blue curve). Apostle MiniMax High Efficiency cfDNA Isolation Kit (Type S) offers >95% recovery of the cfDNA reference standard, which has significant portion of DNA fragments with size <100 bp.

Exhibit 2. Superior small DNA isolation efficiency.

B) cfDNA reference standard was spiked in TE buffer, followed by isolation with MiniMax Type S and a major alternative product. Bioanalyzer 2100 analysis demonstrated significantly higher cfDNA recovery rate of MiniMax Type S (red curve) compared to a major alternative product (blue curve).

Exhibit 3. Superior small DNA isolation efficiency.

C) Zoom in of B)in the region between 35–100 bp. MiniMax Type S (red curve) is compared to a major alternative product (blue curve). Bioanalyzer 2100 analysis demonstrated the efficient recovery at ~50 bp of MiniMax Type S (red curve), while a major alternative product (blue curve) failed.

2024年2月,美国MD Anderson癌症中心科学家团队领衔的一项新临床研究发表在Cell子刊 Cancer Cell (影响因子 50.3),建立了临床证据和方法,使用肿瘤cfDNA 甲基化分析可以有效区分小细胞肺癌(SCLC) 亚型,并用于指导SCLC 治疗方案。 在论著的方法学部分,Apostle MiniMax cfDNA 试剂盒被明确列在“关键商业试剂” (Critical commercial assays)表格中,作出自己应用的贡献。Apostle 艾铂图 MiniMax 游离核酸技术不断在国际上得到广泛的应用,迄今,已发表、被引用 Nature 子刊 4篇 ( Nature Medicine X 2, Nature Communications X 2), Science 子刊 1 篇, PNAS 1 篇,各种临床研究60余篇,作者单位来自60余国际领先的医学研究和临床单位。 祝贺此临床研究团队!期待Apostle 艾铂图技术更好地为人类做贡献。