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全球首台大体积、全自动 cfDNA 自动化提取设备：MagTouch 3000
无需再分为多个2mL样本；在一管内直接处理6-10mL 血浆或尿液 关于我们 MiniMax cfDNA cfRNA MagTouch 保存管 MiniEnrich片段筛选 相关实验室消耗品 产品目录 文献引用 .... ....
业界最优的cfDNA分离技术:MiniMax
在许多国际领先的研发或临床实验室中应用 关于我们 MiniMax cfDNA cfRNA MagTouch 保存管 MiniEnrich片段筛选 相关实验室消耗品 产品目录 文献引用 .... ....
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产品在全球2000万人中应用并不断增长 关于我们 MiniMax cfDNA cfRNA MagTouch 保存管 MiniEnrich片段筛选 相关实验室消耗品 产品目录 文献引用 .... ....
广泛应用，优异的价格体系
高质量 价格优 为您节约成本 关于我们 MiniMax cfDNA cfRNA MagTouch 保存管 MiniEnrich片段筛选 相关实验室消耗品 产品目录 文献引用 .... ....
首创的高分辨片段筛选技术:MiniEnrich
高精度筛选分离核酸短片段,发表于Analyst (封面文章) 关于我们 MiniMax cfDNA cfRNA MagTouch 保存管 MiniEnrich片段筛选 相关实验室消耗品 产品目录 文献引用 .... ....
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一键式自动化 节约您的时间 关于我们 MiniMax cfDNA cfRNA MagTouch 保存管 MiniEnrich片段筛选 相关实验室消耗品 产品目录 文献引用 .... ....
艾铂图 Apostle 产品在全球2000万人中应用并不断增长

为何选择艾铂图 Apostle

基于液体活检、NGS等新兴技术的实验室检测服务，虽然具有技术上的显著进步，但试剂成本高昂。艾铂图 Apostle 为健康产业和社群服务，为研发和临床实验室提供高质量、低成本的产品：
  • 全球领先的产品技术表现
  • 显著的成本节约
  • 一流的技术支持
  • 环境保护
因此，在全球，越来越多的研发和临床实验室切换为艾铂图 Apostle技术方案。

优异表现 - 头对头比较数据



Results and discussion

Mean cfDNA concentrations in the eluates were determined to be 8.30 ng/μL for samples extracted with the QIAamp kit and 11.15 ng/μL for samples extracted with the Apostle kit when measured with the Qubit assay (Figure 1A). This illustrates a 34.3% higher yield when using the Apostle kit as compared to the QIAamp kit.

When evaluating the contents of specific genes in the eluate, the Apostle purification displayed a higher yield than QIAamp (Figure 1B). 8358 DNAJC5G positive droplets were detected in the Apostle samples compared to 7269 droplets in the QIAamp samples. Similarly, 10849 ACTG1 droplets were detected in the Apostle-extracted samples versus 9463 droplets detected in the QIAamp-extracted samples. This data demonstrates an average of 14.8% higher yield using the Apostle kit.

Finally, when evaluating cfDNA fragments via the Agilent bioanalyzer instrument, the Apostle kit demonstrated the highest yield (Figure 1C and D). Mononucleosomal cfDNA concentration in the eluate of Apostle samples was estimated to be 10.64 ng/μL versus 6.26 ng/μL in the eluate of QIAamp samples. The dinucleosomal cfDNA concentration was low for both kits, with 0.13 ng/μL recorded for Apostle samples and 0.24 ng/μL for QIAamp samples. This indicates a slightly better purification of dinucleosomal cfDNA using QIAamp; however, this could also be an artifact given the low concentrations. The Apostle mononucleosomal cfDNA yield was 70.0% higher than the yield for the QIAamp samples.

Publication: Comparative analysis of cell-free DNA extraction efficiency from plasma.  Beckman Coulter Life Sciences. Indianapolis, IN. Technical Note 2022.


A summary provided in Table 2 shows the consistently higher yield achieved by the Apostle MiniMax High Efficiency cfDNA Isolation Kit as compared to the QIAamp® circulating nucleic acid kit. The average 40% improvement in yield underscores the importance of extraction kit selection in cfDNA assay development and highlights the potential impact of cfDNA isolation efficiency in ctDNA detection.


Publication: Comparative analysis of cell-free DNA extraction efficiency from plasma.  Beckman Coulter Life Sciences. Indianapolis, IN. Technical Note 2022.

 

(Figure 4) - "Most notably, the Apostle particles outperformed all others, achieving almost 2-fold higher recovery yields than the particles supplied in the Qiagen kit. "

Publication:  High-throughput sample processing for methylation analysis in an automated, enclosed environment.  Stark et al. SLAS Technology 2022; 27(3):172-179. 


Publication:  Optimization of high-volume cell free DNA extraction and end-to-end automation for TSO 500 ctDNA library prep [abstract]. Nripesh Prasad, Rachel Rock, Rebecca Beatty, Melanie Robinson, Dineen Wildman, Michael Sykes, Boris Umylny, Thomas Halsey. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 2298. 



Figure 1. cfDNA extraction method affects allele frequency (AF%). EGFR L858R standards with AF% of 0.3%, 1.0%, and 3.0% were spiked into plasma and isolated using Product A (red) or Apostle MiniMax cfDNA isolation kit (blue and green). The eluates were analyzed by NGS (performed by the Institute B) following standard protocol and AF% calculated using their established workflow. cfDNA isolated by Apostle MiniMax cfDNA isolation kit shows higher concordance between detected AF% and expected AF%.

Publication: cfDNA Extraction Efficiency Affects NGS Data.   Beckman Coulter Life Sciences. Indianapolis, IN. Technical Note 2020.




(Figure 1) "For each tube the Apostle MiniMax extracted higher total yield of DNA. "


Publication: cfDNA Extraction from Plasma for Liquid Biopsy: Apostle MiniMaxTM High Efficiency cfDNA Isolation Kit. Beckman Coulter Life Sciences, Data Sheet. 2019. 



(Note: Table 13 referenced below in this diploma thesis shows that Apostle MiniMax yields the greatest number of analyzable drops in the digital PCR.)


Publication. Optimalizace digitální polymerázové řetězové reakce pro aplikaci v neinvazivní prenatální diagnostice (Optimization of digital polymerase chain reaction for application in non-invasive prenatal diagnostics) Author: Šenkyřík, Pavel; Advisor: Korabečná, Marie; Referee: Vodička, Radek; Faculty / Institute: Faculty of Science; Discipline: Anthropology and Human Genetics; Department: Department of Anthropology and Human Genetics; Date of defense: 13. 9. 2022; Publisher: Univerzita Karlova, Přírodovědecká fakulta;  Language: Czech

艾铂图 Apostle: 全球表现最优的 cfDNA 游离核酸提取技术
艾铂图 Apostle: 全球表现最优的 cfDNA 游离核酸提取技术
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Apostle MiniMax High Efficiency Cell-Free DNA Isolation Kit (5mL x 50 preps, Standard Edition) Apostle MiniMax High Efficiency Cell-Free DNA Isolation Kit (5mL x 50 preps, Standard Edition)
Apostle MiniMax High Efficiency Cell-Free DNA Isolation Kit (5mL x 50 preps, Standard Edition)
Apostle MiniMax High Efficiency Cell-Free DNA Isolation Kit (Standard Edition) (5mL x 50 preps)Powered by Apostle MiniMax technology, Apostl..
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Apostle MiniMax 高效游离DNA分离试剂盒

高效地分离和分析极低浓度的游离DNA (cfDNA)，在生物医学领域正变得越来越重要，尤其是应用于无创产检（NIPT）、肿瘤的早期筛查和随访、感染性疾病等重要的科研和临床领域。在复杂的生物样本中首先对cfDNA进行高效分离，是随后对其进行有效分析的至关重要一步。与其他传统技术相比，Apostle MiniMax 技术具有全球领域内表现最佳的cfDNA 捕获、分离、纯化的效率和纯度。这一极佳的能力，在全球领域内被广泛地验证和引用。请参阅我们的客户文献和评价数据。
部分已发表的应用案例:
    • Integrative modeling of tumor genomes and epigenomes for enhanced cancer diagnosis by cell-free DNA. Nature Communications 2023;14:2017
    • Simultaneous analysis of mutations and methylations in circulating cell-free DNA for hepatocellular carcinoma detection. Science Translational Medicine 2022;14:672
    • Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results. Nature Medicine 2022;28: 1619-1629
    • Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial. Nature Medicine 2022; 28:1022-1030
    • Efficient detection and post-surgical monitoring of colon cancer with a multi-marker DNA methylation liquid biopsy. PNAS 2021;118 (5) e2017421118
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艾铂图 Apostle: 全球表现最优的 cfDNA 游离核酸提取技术

Apostle MiniMax 游离 DNA 采血保存管

基于独特的Apostle MiniMax技术， Apostle MiniMax游离DNA采血保存管是在外周血液的采集、保存、运输过程中对血液中游离DNA进行保存的绝佳工具。
Apostle游离DNA采血保存管具有以下性能特点：
  • 防止血液在保存和运输过程细胞破裂释放基因组DNA，导致对游离DNA的污染
  • 防止血液中游离DNA的降解
  • 防止血液中游离DNA与其他生物大分子（如蛋白）产生交联
总结：Apostle MiniMax游离DNA采血保存管可以通过防止游离DNA的污染、降解、交联，从而确保高质量的游离核酸用于成功的下游应用。

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Apostle MiniMax cf-DNA Blood Collection Tube (100 pcs) Apostle MiniMax cf-DNA Blood Collection Tube (100 pcs)
Apostle MiniMax cf-DNA Blood Collection Tube (100 pcs)
Powered by Apostle MiniMax technology, Apostle MiniMax cfDNA Blood Collection Tube (BCT) is an excellent tool for blood cfDNA preservation during bloo..
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极佳表现的游离 RNA 分离技术
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Apostle MiniMax High Efficiency cf-RNA Isolation Kit (200uL x 50 preps) Apostle MiniMax High Efficiency cf-RNA Isolation Kit (200uL x 50 preps)
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Apostle MiniMax High Efficiency cfRNA Isolation Kit offers superior isolation efficiency of cell-free RNAs between 17 nt to 1000 nt, without phenol or..
$268.38
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Apostle MiniMax 高效游离RNA分离试剂盒

Apostle MiniMax 高效游离RNA分离试剂盒以极佳的效率分离17 nt 到1000 nt 的游离RNA，不含苯酚或氯仿。 分离的游离RNA产物可以用于广泛的下游应用，如高通量测序、PCR等。 适合用于处理多种血液采集管收集的血液样品。 >

  • 已发表的应用案例: Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification. Wang et al. Nature Communications 15, Article number: 156 (2024).
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适合无创产检和肿瘤无创检测的新一代的短片段核酸富集技术

Apostle MiniEnrich 短片段核酸富集试剂盒

精确地对DNA片段大小进行筛选，可以有效地提高测序的效率、降低成本、提高数据质量，甚至可以对样品量太低、原本无法测序的极端情况进行有效测序。然而，目前普遍的DNA片段大小筛选技术无法对200 bp 以下的DNA短片段进行高分辨率(<20 bp)的区分。Apostle MiniEnrich 短片段富集技术，基于Apostle 特有的纳米磁珠技术，是一个操作简单、可自动化、高分辨率的DNA片段富集技术，可以有效探索20 bp 的高分辨率，将母亲血液中的胎儿DNA片段有效富集，或将肿瘤病人血液中的循环肿瘤DNA有效富集。

  • 发表文献: High-resolution DNA size enrichment using a magnetic nano-platform and application in non-invasive prenatal testing. Zhang et al. Analyst July 2020, 145, 5733-5739 (PDF)
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Apostle MiniEnrich Short Fragments Enrichment Kit (20uL x 50 preps) Apostle MiniEnrich Short Fragments Enrichment Kit (20uL x 50 preps)
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Apostle MiniEnrich for Enrichment of Short DNA fragments for NIPT and Oncology ApplicationsPrecise DNA sizing can boost sequencing efficiency, reduce ..
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新一代核酸纯化、片段大小筛选、长片段筛选技术
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Apostle MiniEnrich Carboxyl Beads for Purification (30mL) (AMPure XP alternative) Apostle MiniEnrich Carboxyl Beads for Purification (30mL) (AMPure XP alternative)
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Next-generation purification, size selection, and long-read size selection.The Apostle MiniEnrich Purification Beads is designed for purification and ..
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Apostle MiniEnrich 羧基纯化磁珠

新一代核酸纯化、片段大小筛选、长片段筛选技术

Apostle MiniEnrich 纯化磁珠特别设计用来对DNA片段进行纯化和筛选，去除污染物。广泛应用于NGS高通量测序以及其他分子生物学操作流程中，包括文库制备、PCR扩增、克隆等。与其他普遍产品相比，Apostle MiniEnrich特有的技术可以更高效地去除污染物和回收目标片段。

  • 发表文献: High-resolution DNA size enrichment using a magnetic nano-platform and application in non-invasive prenatal testing. Zhang et al. Analyst July 2020, 145, 5733-5739 (PDF)
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艾铂图 Apostle 产品在全球2000万人中应用并不断增长

MagTouch 2000

MagTouch 2000自动化设备是可用于来自多种储存转运媒介、多种生物样本类型的自动化核酸提取和纯化系统。MagTouch 2000通过特殊设计的磁棒和磁棒套自动完成吸附、转移、释放艾铂图Apostle的专利纳米磁珠，实现自动化分离纳米磁珠和生物样本，以达到高效率地从生物样本中分离核酸。MagTouch 2000的操作非常简单、快速和自动化。对比我们之前的MagTouch 1000设备，新型的MagTouch 2000更容易使用、更坚固耐久，并且占用的实验室台面面积更小，更经济有效。

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艾铂图 Apostle 产品在全球2000万人中应用并不断增长
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Apostle NanoFlex 800 微量分光光度计 + 荧光计 Apostle NanoFlex 800 微量分光光度计 + 荧光计
Apostle NanoFlex 800 微量分光光度计 + 荧光计
 Apostle NanoFlex 800 微量分光光度计可以检测0.5-2μL 的样本，并且具有非常高的准确性和重复性。样本保留系统应用表面张力把样本保留在两根检测光纤中间，使得仪器可以检测较高浓度的样本而不用稀释。应用该技术，全波长（200-800nm）Apostle Nan..
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NanoFlex 800

Apostle NanoFlex 800 微量分光光度计可以检测0.5-2μL 的样本，并且具有非常高的准确性和重复性。样本保留系统应用表面张力把样本保留在两根检测光纤中间，使得仪器可以检测较高浓度的样本而不用稀释。应用该技术，全波长（200-800nm）Apostle NanoFlex 800 微量分光光度计所能检测样本的最高浓度是标准比色皿的上千倍。此外， Apostle NanoFlex 800 还具有内置荧光检测功能，是微量分光光度计和荧光计一体机。 Apostle NanoFlex 800 微量分光光度计可用于：核酸检测、蛋白A280检测、比色法检测、荧光计检测、Uv-Vis全波长扫描、OD600检测等多种功能领域的检测。

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艾铂图 Apostle 产品在全球2000万人中应用并不断增长

客户评价、引用、报道和反馈

【Cancer Cell】Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes
"These data establish that tumor and cfDNA methylation can be used to identify SCLC subtypes and might guide precision SCLC therapy. "..."(Methods section) cfDNA was extracted using the Apostle MiniMax High Efficiency Cell-Free DNA Isolation Kit (Apostle Inc). " ..."(Key Resources Table - Critical commercial assays) Apostle MiniMax High Efficiency Cell-Free DNA Isolation Kit. Apostle Bio A17622-250 "
- 发表于 Cell 子刊 Cancer Cell（影响因子 50.3） 的独立临床研究，作者第一单位: MD Anderson癌症中心
【Nature Communications】Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification
"We perform transcriptome-wide characterizations in 165 lung cancer, 30 breast cancer, 37 colorectal cancer, 55 gastric cancer, 15 liver cancer, and 133 cancer-free participants and demonstrate its ability to identify transcriptomic changes occurring in early-stage tumors. "..."(Methods section) 200 μl of plasma samples were subjected to cfRNA extraction using the Apostle MiniMax High-Efficiency cfRNA Isolation Kit (Apostle), following the manufacturer’s protocol with minor modifications. "
- 发表于 Nature Communications 的独立临床研究
【Nature Communications】Integrative modeling of tumor genomes and epigenomes for enhanced cancer diagnosis by cell-free DNA
"Our integrative model detects early-stage cancers, including those of pancreatic origin, with high sensitivity that is comparable to that of late-stage detection. "..."(Methods section) cfDNA was extracted from 0.4 mL plasma ... and eluted in a final volume of 22 μL, using an Apostle MiniMax High Efficiency cfDNA Isolation Kit (Apostle, US) according to the manufacturer’s instructions. "
- 发表于 Nature Communications 的独立临床研究
【Nature Medicine】 Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results
"Exploratory biomarker analyses showed decreased circulating tumor DNA (ctDNA) in patients with prolonged OS... cfDNA was extracted from the entire plasma volume of a single draw using the Apostle MiniMax cfDNA Isolation kit (ApostleBio) "
- 发表于 Nature Medicine 的独立临床试验，参与单位： 美国Gritstone, 美国哥伦比亚大学医学院，美国梅奥诊所，美国MSKCC 纪念斯隆凯特琳癌症中心，美国MD Anderson癌症中心。
【Science Translational Medicine】Simultaneous analysis of mutations and methylations in circulating cell-free DNA for hepatocellular carcinoma detection
"The model detected four of the five HCC cases in the cohort, showing 80% sensitivity and 94% specificity. These findings demonstrate that the MCP technology has potential for the discovery and validation of multiomics biomarkers for the noninvasive detection of cancer. This study also provides a comprehensive database of genetic and epigenetic alterations in the cfDNA of a large cohort of HCC cases and high-risk non-HCC individuals." "cfDNA was extracted from the plasma samples using the Apostle MiniMax cfDNA isolation kit (C43468, Apostle). "
- 发表于 Science Translational Medicine 的独立临床研究，参与单位：中国国家癌症中心，泛生子等
【Nature Medicine】Safety and tolerability of AAV8 delivery of a broadly neutralizing antibody in adults living with HIV: a phase 1, dose-escalation trial
"In this study, we administered a recombinant bicistronic adeno-associated virus (AAV8) vector coding for both the light and heavy chains of the potent broadly neutralizing HIV-1 antibody VRC07 (AAV8-VRC07) to eight adults living with HIV... Plasma AAV8-VRC07 plasmid DNA was measured by extracting DNA from plasma,... DNA was extracted from serum using an Apostle MiniMax High Efficiency cfDNA Isolation Kit, following the manufacturer’s protocol with slight modification."
- 发表于 Nature Medicine 的独立临床试验，参与单位：美国NIH, 美国南卡罗莱纳大学医学院，美国麻省理工学院和哈佛大学，美国加州理工，美国杜克大学，美国Vaxart, 以及ModeX。
"The mqMSP assay is cost-effective and easily implementable for routine clinical monitoring of CRC recurrence, which can lead to better patient management after surgery... Plasma DNA extraction was performed using 2 to 5 mL of plasma with the Apostle MiniMax High-Efficiency cfDNA Isolation Kit, according to the product manual. "
- 一项独立临床研究，发表于 PNAS
"This illustrates a 34.3% higher yield when using the Apostle kit as compared to the X kit." "This data demonstrates an average of 14.8% higher yield using the Apostle kit." "The Apostle mononucleosomal cfDNA yield was 70.0% higher than the yield for the X samples." "A summary provided in Table 2 shows the consistently higher yield achieved by the Apostle MiniMax High Efficiency cfDNA Isolation Kit as compared to the X circulating nucleic acid kit. The average 40% improvement in yield underscores the importance of extraction kit selection in cfDNA assay development and highlights the potential impact of cfDNA isolation efficiency in ctDNA detection."
- 一项独立比较研究，作者：美国贝克曼库尔特公司 (文献全文)
(Figure 4) "Most notably, the Apostle particles outperformed all others, achieving almost 2-fold higher recovery yields than the particles supplied in the X kit".
- 一项发表在 SLAS Technology 上的独立临床研究，参与单位：美国约翰霍普金斯大学，匹兹堡大学
"We used SMS-based NIPS to screen for common fetal aneuploidies in 477 pregnant women." "Compared with NGS, SMS (without PCR) had less GC bias, a better distinction between T21 or T18 and euploidies, and better diagnostic performance. " "cfDNA was extracted from 0.6 mL of maternal plasma using Apostle MiniMax High-Efficiency cfDNA Isolation Kit (ref. number: A17622-50; Apostle) according to the manufacturer’s instructions."
- 一项发表在 Laboratory Investigation 上的独立临床研究，参与单位：浙江大学医学院附属妇产科医院，教育部生殖遗传重点实验室，等
"H3K36me3 cfChIP-seq demonstrated increased enrichment of mutated alleles compared to normal alleles in plasma from patients with known somatic cancer mutations." "Findings here expand the utility of cfDNA in liquid biopsies to characterize treatment resistance, cancer subtyping, and disease progression." "Both the input as well as the cfChIP samples were purified using Apostle MiniMax High Efficiency cfDNA Isolation Kit (Beckman Coulter, Indianapolis, IN, USA) according to manufacturer’s instructions."
- 一项发表于 Molecular Oncology 的独立临床研究，作者单位： Department of Clinical Biochemistry, Aarhus University Hospital, and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
"Plasma cell-free DNA (cfDNA) from 2821 myeloid or lymphoid neoplasm patients were collected. cfDNA was sequenced using a 275 gene panel... This data shows that liquid biopsy using targeted NGS is reliable in detecting chromosomal structural abnormalities in myeloid neoplasms...Overall, this study supports the use of liquid biopsy for early diagnosis and monitoring of patients with myeloid neoplasms...We extracted cfDNA from 2821 peripheral blood samples using the Apostle MiniMax High Efficiency cfDNA Isolation Kit (San Jose, CA). "
- 发表于 Frontiers in Oncology 的独立临床研究，参与单位：美国Hackensack University Medical Center, Ernest Mario School of Pharmacy at Rutgers University, Englewood Health Internal Medicine Residency Program, 以及Genomic Testing Cooperative。
"...Elucidating the relationship between these pathways and the increased circulating mitochondrial DNA observed here will provide further insight into the cell-damaging effects of prolonged inhalation of e-cigarette aerosols. " "For measurement of in vivo plasma mtDNA/nDNA ratio, mice plasma was first subjected to cell-free DNA (cfDNA) extraction using Apostle minimax cfDNA extraction kit (ApostleBio, CA, US). "
- 一项发表于 American Journal of Cancer Research 美国癌症研究杂志 的独立临床研究，参与单位：美国耶鲁大学
As a proof-of-concept, we developed a 222-plex Ultra-dPCR assay and demonstrated its potential use as a rapid, low-cost screening assay for non-invasive prenatal testing (NIPT) for as low as 4% trisomy fraction samples with high precision, accuracy, and reproducibility...Cell-free plasma was isolated using the Apostle MiniMax kit (Beckman Coulter) according to the manufacturer’s protocol with an elution volume of 60 μL.
- 一项发表于 Analytical Chemistry 的独立研究，参与单位：Enumerix
"We developed a ddPCR assay to quantify the T790M mutation in plasma. Quantification of longitudinal plasma T790M mutation may allow noninvasive assessment of drug resistance and guide follow-up treatment in TKI-treated patients with NSCLC....cfDNA was extracted from 2–6 ml of plasma using an Apostle MiniMax High Efficiency cfDNA Isolation Kit (standard edition) (Apostle, Silicon Valley, CA, USA) according to the manufacturer’s instructions. "
- 一项发表于 Targeted Oncology 的独立临床研究
"Therefore, wastewater monitoring for SARS-CoV-2 variants in the community is a feasible strategy as a complementary tool to clinical specimen testing in the latter's absence. " "The NP swabs received at the Nevada State Public Health Laboratory (NSPHL) from the Reno-Sparks metropolitan for SARS-CoV-2 diagnostic testing were subjected for RNA extraction using Virus Total NA Isolation Fast Kit (Apostle MiniGenomics, San Jose, CA, USA)"
- 一项发表于 Scientific Reports 的独立临床研究，作者单位：美国内华达州立公共卫生实验室 Nevada State Public Health Laboratory
Apostle COVID-19 RNA Extraction System is a fast and reliable solution for SARS-CoV-2 viral RNA extraction. We look forward to continuing the collaboration with Apostle and providing high quality COVID-19 tests for our community.
- Harry Gao, MD, PhD, DABMG, FACMG, Fulgent Genetics (纳斯达克股票代码: FLGT)临床CLIA/CAP实验室主任，首席科学官
With Apostle automation, my team and I have been able to develop a method to detect and quantify SARS-CoV-2 in wastewater samples, while also having the ability to sequence viral RNA from the wastewater samples. ...Apostle was able to quickly supply us with instruments, plates and reagents for a fraction of the price of the competitors. Apostle has been a great partner for us. Their technical support team programmed our MagTouch 2000 at no cost, and their team was supportive and accommodating every step of the way.
- Lauryn Massic, 美国内华达州立公共卫生实验室 (Nevada State Public Health Laboratory) 感染性疾病学者 (采访全文)
(Figure 1) "For each tube the Apostle MiniMax extracted higher total yield of DNA".
- 一项独立研究，作者：美国贝克曼库尔特公司 (文献全文)
"The combination of mutation profiling and CNA profiling can improve the detection of MRD, which may help optimize the treatment strategies for patients with locally advanced rectal cancer (LARC)...cfDNA was extracted from 1.5-4.5 mL of plasma with the Apostle MiniMax cfDNA isolation kit (C40605, Apostle; San Jose, CA, USA). "
- 一项发表于 EBioMedicine 的独立临床研究，参与单位：北京协和医学院，中山大学癌症中心，等
"An instance of sequential infection of an individual with, firstly, the Delta variant and secondly a Delta-sub-lineage has been identified. The individual was found positive for the AY.26 lineage 22 days after being found positive for the Delta [B.1.617.2] variant...Nucleic acid extractions were performed by Apostle MagTouch Nucleic Acid Extraction Automation Systems [Apostle Inc, San Jose, CA]. "
- 一项发表于 Diagnostic Microbiology and Infectious Disease 的独立临床研究，作者单位：美国内华达州立公共卫生实验室 Nevada State Public Health Laboratory
"...This includes recognizing that an innovative product from Apostle is the best technology to address these needs."
- Steve Wowk, 美国贝克曼库尔特公司，基因组学总监
"Our study confirmed that SD regions are preferred biomarkers for aneuploidy detection and in particular SD-based digital PCR could find potential use for NIPT of trisomy... The cfDNA was isolated from 1 mL of each plasma sample by the Apostle MiniMax™ High Efficiency cfDNA Isolation Kit (Apostle Inc, San Jose, CA). "
- 一项发表于 EBioMedicine 的独立临床研究，作者单位：厦门大学分子疫苗学和分子诊断学国家重点实验室
"Magnetic beads-based DNA extraction using the supernatant from the homogenized stool was chosen for further analysis due to better reproducibility, higher hgDNA yield, lower non-hgDNA background, and the potential for automation. ...achieved a sensitivity and specificity of 81.82 and 93.75%, respectively...Through the systematic evaluation of different stool processing and DNA extraction methods, we established a reproducible protocol for analyzing tumor DNA methylation markers in stool samples for colorectal cancer screening...Apostle Stool gDNA Isolation Kit (APOSTLE) was used according to the manufacturer’s instructions. Either 0.2 g pellets or 0.2 mL supernatant from homogenized stool was mixed with 1 mL lysis buffer (APOSTLE) for DNA extractions. "
- 一项发表于 Clinical Chemistry and Laboratory Medicine (CCLM) 的独立临床研究
"BGI Genomics announces that its Stool Sample Collection Kit, DNA Isolation Kit together with Sample Pretreatment Kit for Methylation Detection have been CE marked. " (Note by Apostle: Apostle is the Original Equipment Manufacturer or OEM for the Stool DNA Isolation Kit mentioned in this news. )
- BGI 华大基因
客户文献引用和报道

下列机构的科学家引用、应用艾铂图Apostle的技术。如有发表文献可以点击阅读。

Apostle 艾铂图在2023年AACC 美国临床化学年会上的展览顺利圆满结束！AACC美国临床化学学会今年起正式更名为ADLM（Association for Diagnostics and Laboratory Medicine) 美国诊断学和实验室医学学会，更加贴合领域和学科，是全世界最大的临床实验室学术机构和年展。感谢Apostle 艾铂图的国际、国内客户对我们的支持和关注！我们会一如既往，为社群提供高质、价优的临床和研发实验室产品，不懈努力，为人类健康服务！

公司新闻

2024年2月1日

【Cancer Cell】Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes

小细胞肺癌（SCLC）是有多重亚型的恶性肿瘤，但目前临床对亚型进行区分却有很大挑战。此项新临床研究，由美国MD Anderson癌症中心科学家团队领衔，发表在Cell子刊 Cancer Cell（影响因子 50.3），建立了临床证据和方法，使用肿瘤cfDNA 甲基化分析，可以有效区分SCLC 亚型，并用于指导SCLC 治疗方案。  在论著的方法学部分，Apostle MiniMax cfDNA 试剂盒被明确列在“关键商业试剂” （Critical commercial assays）表格中，作出自己应用的贡献。


祝贺此临床研究团队！Apostle 艾铂图 MiniMax 游离核酸技术不断在国际上得到广泛的应用，迄今，已发表、被引用Nature 子刊 4篇，Science 子刊 1 篇，PNAS 1 篇，各种临床研究60余篇，作者单位来自60余国际领先的医学研究和临床单位。 期待Apostle 艾铂图技术更好地为人类做贡献。  ...阅读原文


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关于我们

艾铂图 Apostle是一家国际生物科技公司，是公共健康技术与服务提供者。公司全球总部位于美国加利福尼亚州旧金山湾区普莱森顿市，拥有自有独立园区；中国区总部位于江苏省南京市。艾铂图 Apostle 致力于研发业界领先的原创性实验室技术，尤其着重于应用于液体活检的 Apostle MiniMax cfDNA 分离技术和cfDNA 保存技术、Apostle MiniGenomics 和 MagTouch 核酸分离技术、等许多其他新技术产品及服务，并以此服务于公共健康和生命科学；与此同时，也是美国联邦 CLIA 授权，CAP 认证，拥有加利福尼亚州政府执照的临床检测机构，切实践行每日服务人群健康安全。艾铂图 Apostle 的创新型科技产品、国际化的临床实验室已经为全球超过2000万人提供服务，我们艾铂图 Apostle人的每一日，都踏实努力践行我们的使命：研发业界领先的原创性技术，并以此服务于公共健康和生命科学。
关于我们
全球总部: 3589 Nevada St, Pleasanton, CA ,USA 94566
全球总部: 3589 Nevada St, Pleasanton, CA ,USA 94566
全球总部: 3589 Nevada St, Pleasanton, CA ,USA 94566
中国区总部：江苏省南京经济开发区智芯路4号红枫科技园B3栋11层，210000
中国区总部：江苏省南京经济开发区智芯路4号红枫科技园B3栋11层，210000
中国区总部：江苏省南京经济开发区智芯路4号红枫科技园B3栋11层，210000
中国区总部：江苏省南京经济开发区智芯路4号红枫科技园B3栋11层，210000
2024年2月，美国MD Anderson癌症中心科学家团队领衔的一项新临床研究发表在Cell子刊 Cancer Cell （影响因子 50.3），建立了临床证据和方法，使用肿瘤cfDNA 甲基化分析可以有效区分小细胞肺癌(SCLC) 亚型，并用于指导SCLC 治疗方案。 在论著的方法学部分，Apostle MiniMax cfDNA 试剂盒被明确列在“关键商业试剂” （Critical commercial assays）表格中，作出自己应用的贡献。Apostle 艾铂图 MiniMax 游离核酸技术不断在国际上得到广泛的应用，迄今，已发表、被引用 Nature 子刊 4篇 ( Nature Medicine X 2, Nature Communications X 2)， Science 子刊 1 篇， PNAS 1 篇，各种临床研究60余篇，作者单位来自60余国际领先的医学研究和临床单位。 祝贺此临床研究团队！期待Apostle 艾铂图技术更好地为人类做贡献。